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English Name: 2,6-Lutidine
Nickname: 2,6- lutidine 2,6- two methyl pyridine
Molecular formula: C7H9N
Molecular weight: 107.15
CAS NO: 108-48-5
Melting point: -6 degree C
Boiling point: 143-145 degree C
Water solubility: soluble in cold water, soluble in hot water, ethanol and ether
Density: 0.92 at C 25 degree g/mL
Appearance: colorless oily liquid
Flash point: 92 ~ F
Property and stability
1 chemical properties are alkaline, can with inorganic acid, organic acid production salt. Addition of compounds with inorganic salts and alkyl halide. The two generation of 2,6- methyl piperidine hydrogenation. With potassium permanganate oxidation, generating two -2,6- pyridine carboxylic acid. Under the action of the dehydrogenation catalyst, the 2,6- two methyl pyridine gas phase becomes 2- methyl pyridine and pyridine.
2 has the stimulation, to the nervous system, the liver, the kidney to have the damage function. Contact with the eyes, skin and mucous membrane appear to stimulate the symptoms, and cause headaches, dizziness, nausea, vomiting, mental retardation, abdominal pain, diarrhea, etc.. This product is flammable, in case of high fever, fire can cause combustion and explosion. Heat decomposition to emit toxic nitric oxide flue gas. The contact with the oxidant will react violently. Combustion (decomposition) products are carbon monoxide, carbon dioxide, nitrogen oxides. Therefore the use of this product should be carried out in a hood.
3 stability
4 strong oxidizing agents, acids, acyl chloride, and acid anhydride
5 polymerization hazard does not aggregate
Storage method
1 store notes [30] stored in a cool, ventilated warehouse. The temperature should not exceed 37 DEG C. Away from the fire, heat source. Packaging requirements are sealed and can not be contacted with air. Should be stored with the oxidant, acids, etc., should not be mixed. Explosion proof lighting and ventilation facilities. Mechanical equipment and tools for the prohibition of the use of easy to produce sparks. The storage area should be equipped with a leak emergency treatment equipment and a suitable shelter material.
2 warehouses in a cool ventilated, away from the fire fire, the temperature is below 30 degrees Celsius, the direct sunlight. Reagents: 100ml500ml reagent bottles; industrial products: 20kg/ barrels 18kg/ barrels. Place ventilated and dry place
synthetic method
1. The recovery of the beta methyl pyridine fraction from the byproduct of the coal coking byproduct is obtained.
Usually containing 3- and 4- methyl pyridine, difficult to use fractionation method separation. General use and water composition of the boiling mixture (a total of 95.5~96 degrees Celsius), the purpose of distillation to achieve separation. The other is formed with urea adduct separation method; separation method for generating hydrochloride; sulfate nickel nitrite and ammonium thiocyanate in mixed solution, the 3- and 4- methyl pyridine adduct formation and removal method etc..
2, method of ethyl acetoacetate ethyl acetoacetate by cyclization, oxidation, hydrolysis, alkali solution prepared.
purpose
1 widely used in organic synthesis. The pharmaceutical industry can be used in the production of anti atherosclerosis drugs. It can be used in the production of roundworm, whipworm, Fasciolopsiasis, pinworm and effective broad-spectrum anthelmintic monopar. And cortisone acetate, hydrocortisone, nicotinic acid, Lu Chaplin etc.. Intermediate 2,6- two methyl pyridine can also be used as pesticides, dyes, auxiliaries, resin, rubber vulcanization accelerator, heat stabilizer. This product can be obtained by oxidation of two picolinic acid, hydrogen peroxide and peracetic acid used as stabilizer, can synthesize lobeline. The product can also be used as a solvent. 2,6- two methyl pyridine is used as catalyst in the alkylation reaction of benzene, and can be used as curing agent for epoxy resin.
2 this product is alkaline, silylation reaction can be catalyzed; the reagent can make the deprotection of acetals.
The protection of alcohol in the presence of anhydrous 2,6- two methyl pyridine, hydroxyl silicon etherification, high yield of 99%, the protection of this reaction is commonly used in the synthesis of natural products of hydroxy groups. As in anhydrous dichloromethane (78~0oC), t-Bu (Me) 2SiOTf (TBSOTf) and 2,6- two methyl pyridine can make two alcohol into the silyl ether, so that the hydroxyl group is protected, the reaction is almost quantitative (type 1). T-Bu (Me) 2SiOTf and 2,6- two methyl pyridine can also protect the three alcohols or inactive two alcohols. (Et) 3SiOTf and 2,6- two methyl pyridine can protect the three alcohols with steric hindrance.
TMSOTf 2,6- and deprotection of two methyl pyridine together, can selectively enable chemical deprotection and aldehyde acetal.
The Corey-Fuchs reaction in the presence of Ph3P and 2,6- two methyl pyridine, aldehydes and CBr4 in dichloromethane end reaction of allyl bromide.
Other types of reaction in the presence of 2,6- two methyl pyridine hydrochloride, can make the C-F key into C-H (D) key. In addition, 2,6- two methyl pyridine and other aspects of the application.
3 in medicine can be used to treat all types of hypertension medicine and first aid, and also used as pesticides and AIDS
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